alphagenome.models.variant_scorers.PolyadenylationScorer

class alphagenome.models.variant_scorers.PolyadenylationScorer

Variant scorer for polyadenylation QTLs (paQTLs).

Variant scorer for polyadenylation quantitative trait loci (paQTLs) to capture a variant’s impact on RNA isoform production.

The scoring approach quantifies the maximum log fold change in expression between the set of proximal polyadenylation sites (PAS)s vs. the set of distal PASs, where the sets of proximal and distal PASs are the PASs upstream or downstream of any given 3’ cleavage site respectively.

base_variant_scorer

The base variant scorer.

name

The name of the scorer (a composite of the above attributes that uniquely identifies a scorer combination).

is_signed

Whether this variant scorer is directional (such that scores may be negative or positive) or non-directional (scores are always positive).

to_proto()

Converts the scorer to its corresponding proto message.

Attributes

Table

base_variant_scorer
is_signed
name
requested_output	Returns the scorer's underlying output type.

PolyadenylationScorer.base_variant_scorer

PolyadenylationScorer.is_signed

PolyadenylationScorer.name

PolyadenylationScorer.requested_output

Returns the scorer’s underlying output type.

Methods

Table

to_proto()

PolyadenylationScorer.to_proto()

Return type:

VariantScorer