score_variant

DnaClient.score_variant(interval, variant, variant_scorers=(), *, organism=Organism.HOMO_SAPIENS, merge_stranded_gene_tracks=True)

Generate variant scores for a single given DNA variant.

Parameters:

• interval (Interval) – DNA interval to make prediction for.

• variant (Variant) – DNA variant to make prediction for.

• variant_scorers (Sequence[CenterMaskScorer | ContactMapScorer | GeneMaskLFCScorer | GeneMaskActiveScorer | GeneMaskSplicingScorer | PolyadenylationScorer | SpliceJunctionScorer] (default: ())) – Sequence of variant scorers to use for scoring. If no variant scorers are provided, the recommended variant scorers for the organism will be used.

• organism (Organism (default: <Organism.HOMO_SAPIENS: 9606>)) – Organism to use for the prediction.

• merge_stranded_gene_tracks (bool (default: True)) – If True, merges gene-centric scores from stranded tracks into a single, unstranded track.

Return type:

list[AnnData]

Returns:

List of AnnData variant scores.